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The applicant further opined that, although not explicitly stated, the paper presumably calculated the sample size based on the primary endpoint of stent removal, not to detect any clinical differences and, while Johnson et al

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Bacteriocin expression in commensal bacteria can influence niche occupation in the GIT, and bacteriocins delivered by commensals that occupy a precise intestinal niche may represent an effective therapeutic approach to specifically eliminate intestinal colonisation of VRE without disruption of indigenous microbiota [44, 145, 161]

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